Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.54 |
| ▸ | PDE4A | P27815 | 9/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3786540 | 0.83 | KMT2A (0.53) | POLBPDE4BKMT2AMEN1MAPT | |
| SCHEMBL28479695 | 0.83 | HIF1A (0.52) | POLBPDE4DPDE4BPDE4APDE4C | |
| SCHEMBL10803200 | 0.82 | POLB (0.61) | POLBKMT2AMEN1MAPTHTT | |
| SCHEMBL10796854 | 0.82 | POLB (0.61) | POLBKMT2AMEN1MAPTHTT | |
| SCHEMBL28870890 | 0.82 | PDE4B (0.53) | POLBPDE4DPDE4BPDE4APDE4C | |
| SCHEMBL10802749 | 0.81 | ATM (0.60) | POLBKMT2AMEN1MAPTHTT | |
| SCHEMBL27521810 | 0.80 | PDE4A (0.60) | POLBPDE4DPDE4BPDE4APDE4C | |
| SCHEMBL6864582 | 0.79 | PDE4D (0.58) | POLBPDE4DPDE4BPDE4APDE4C | |
| SCHEMBL17933774 | 0.79 | KMT2A (0.53) | KMT2AHTTSMN1; SMN2TDP1NPC1 | |
| SCHEMBL7417740 | 0.79 | PDE4B (0.50) | POLBPDE4DPDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016134668-A1 | SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2016-09-01 | — | — | WO | disclosed |
| WO-2016000615-A1 | HETEROARYL COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2016-01-07 | — | — | WO | disclosed |