Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 4/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.34 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.34 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.33 |
| ▸ | KCNK3 | O14649 | 5/20 | 0.33 |
| ▸ | KCNK9 | Q9NPC2 | 5/20 | 0.33 |
| ▸ | MTOR | P42345 | 2/20 | 0.32 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.32 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14316244 | 1.00 | RET (0.34) | RETGPR119SUV39H2EIF2AK4KCNK3 | |
| SCHEMBL12461414 | 1.00 | RET (0.34) | RETGPR119SUV39H2EIF2AK4KCNK3 | |
| SCHEMBL14298329 | 1.00 | RET (0.34) | RETGPR119SUV39H2EIF2AK4KCNK3 | |
| SCHEMBL2147933 | 1.00 | RET (0.34) | RETGPR119SUV39H2EIF2AK4KCNK3 | |
| SCHEMBL30766 | 1.00 | RET (0.34) | RETGPR119SUV39H2EIF2AK4KCNK3 | |
| SCHEMBL2147571 | 1.00 | RET (0.34) | RETGPR119SUV39H2EIF2AK4KCNK3 | |
| SCHEMBL28913 | 0.93 | EIF2AK4 (0.33) | RETGPR119SUV39H2EIF2AK4KCNK3 | |
| SCHEMBL2147546 | 0.92 | EIF2AK4 (0.33) | RETGPR119SUV39H2EIF2AK4KCNK3 | |
| SCHEMBL2147553 | 0.92 | EIF2AK4 (0.33) | RETGPR119SUV39H2EIF2AK4KCNK3 | |
| SCHEMBL14298636 | 0.92 | EIF2AK4 (0.32) | RETGPR119SUV39H2EIF2AK4KCNK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9227971-B2 | Pyrazolo[1,5-a]pyrimidine compounds as mTOR inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-01-05 | — | — | US | disclosed |