Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 15/20 | 0.56 |
| ▸ | RPTOR | Q8N122 | 4/20 | 0.56 |
| ▸ | MLST8 | Q9BVC4 | 4/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.33 |
| ▸ | CDK2 | P24941 | 4/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2170325 | 1.00 | MTOR (0.56) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL2170333 | 1.00 | MTOR (0.56) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL2147872 | 1.00 | MTOR (0.56) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL12461531 | 1.00 | MTOR (0.56) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL14246212 | 0.94 | MTOR (0.54) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL14298609 | 0.94 | MTOR (0.54) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL2148172 | 0.94 | MTOR (0.54) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL2147123 | 0.94 | MTOR (0.54) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL14298598 | 0.94 | MTOR (0.54) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL14245926 | 0.94 | MTOR (0.54) | MTORRPTORMLST8CHEK1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9227971-B2 | Pyrazolo[1,5-a]pyrimidine compounds as mTOR inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-01-05 | — | — | US | disclosed |