Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 3/20 | 0.44 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.44 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 7/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.40 |
| ▸ | CDK2 | P24941 | 7/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 7/20 | 0.40 |
| ▸ | RET | P07949 | 4/20 | 0.38 |
| ▸ | KIF5B | P33176 | 4/20 | 0.38 |
| ▸ | KDR | P35968 | 4/20 | 0.38 |
| ▸ | ETV6 | P41212 | 4/20 | 0.38 |
| ▸ | CCDC6 | Q16204 | 3/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | CASP3 | P42574 | 2/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14246059 | 1.00 | MTOR (0.44) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL14298568 | 1.00 | MTOR (0.44) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL14246062 | 1.00 | MTOR (0.44) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL14246049 | 0.91 | CHEK1 (0.48) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL14298572 | 0.91 | CHEK1 (0.48) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL2147852 | 0.91 | CHEK1 (0.48) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL17399421 | 0.91 | CHEK1 (0.48) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL12461004 | 0.87 | MTOR (0.49) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL17399404 | 0.86 | MTOR (0.44) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL12460384 | 0.86 | MTOR (0.44) | MTORRPTORMLST8CHEK1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9227971-B2 | Pyrazolo[1,5-a]pyrimidine compounds as mTOR inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-01-05 | — | — | US | disclosed |