Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 5/20 | 0.42 |
| ▸ | RPTOR | Q8N122 | 5/20 | 0.42 |
| ▸ | MLST8 | Q9BVC4 | 5/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 7/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.34 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.32 |
| ▸ | HPGDS | O60760 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.31 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12461161 | 1.00 | MTOR (0.42) | MTORRPTORMLST8DGAT1GPR119 | |
| SCHEMBL30182 | 1.00 | MTOR (0.42) | MTORRPTORMLST8DGAT1GPR119 | |
| SCHEMBL12460330 | 1.00 | MTOR (0.42) | MTORRPTORMLST8DGAT1GPR119 | |
| SCHEMBL2146976 | 1.00 | MTOR (0.42) | MTORRPTORMLST8DGAT1GPR119 | |
| SCHEMBL12461327 | 1.00 | MTOR (0.42) | MTORRPTORMLST8DGAT1GPR119 | |
| SCHEMBL14298827 | 0.97 | MTOR (0.40) | MTORRPTORMLST8DGAT1GPR119 | |
| SCHEMBL2147097 | 0.97 | MTOR (0.40) | MTORRPTORMLST8DGAT1GPR119 | |
| SCHEMBL15026304 | 0.95 | MTOR (0.37) | MTORRPTORMLST8DGAT1GPR119 | |
| SCHEMBL2147662 | 0.95 | MTOR (0.39) | MTORRPTORMLST8DGAT1GPR119 | |
| SCHEMBL14298832 | 0.95 | MTOR (0.39) | MTORRPTORMLST8DGAT1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9227971-B2 | Pyrazolo[1,5-a]pyrimidine compounds as mTOR inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-01-05 | — | — | US | disclosed |