Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 5/20 | 0.45 |
| ▸ | RPTOR | Q8N122 | 5/20 | 0.45 |
| ▸ | MLST8 | Q9BVC4 | 5/20 | 0.45 |
| ▸ | DGAT1 | O75907 | 5/20 | 0.37 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.31 |
| ▸ | HPGDS | O60760 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2148121 | 1.00 | MTOR (0.45) | MTORRPTORMLST8DGAT1EIF2AK4 | |
| SCHEMBL2148126 | 1.00 | MTOR (0.45) | MTORRPTORMLST8DGAT1EIF2AK4 | |
| SCHEMBL2147099 | 0.94 | MTOR (0.45) | MTORRPTORMLST8DGAT1EIF2AK4 | |
| SCHEMBL2147102 | 0.94 | MTOR (0.45) | MTORRPTORMLST8DGAT1EIF2AK4 | |
| SCHEMBL17399371 | 0.94 | MTOR (0.45) | MTORRPTORMLST8DGAT1EIF2AK4 | |
| SCHEMBL2147742 | 0.92 | MTOR (0.45) | MTORRPTORMLST8DGAT1EIF2AK4 | |
| SCHEMBL17399399 | 0.92 | MTOR (0.45) | MTORRPTORMLST8DGAT1EIF2AK4 | |
| SCHEMBL2148156 | 0.92 | MTOR (0.45) | MTORRPTORMLST8DGAT1EIF2AK4 | |
| SCHEMBL2724052 | 0.92 | MTOR (0.48) | MTORRPTORMLST8DGAT1 | |
| SCHEMBL15807825 | 0.92 | MTOR (0.43) | MTORRPTORMLST8DGAT1EIF2AK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9227971-B2 | Pyrazolo[1,5-a]pyrimidine compounds as mTOR inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-01-05 | — | — | US | disclosed |