Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 11/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.40 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.40 |
| ▸ | ITGAL | P20701 | 1/20 | 0.40 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17400716 | 1.00 | MPL (0.52) | MPLADORA3S1PR1ITGB2ICAM1 | |
| SCHEMBL17400640 | 0.96 | MPL (0.51) | MPLADORA3S1PR1ITGB2ICAM1 | |
| SCHEMBL17400577 | 0.96 | MPL (0.53) | MPLADORA3S1PR1ITGB2ICAM1 | |
| SCHEMBL17400509 | 0.94 | MPL (0.52) | MPLADORA3S1PR1ITGB2ICAM1 | |
| SCHEMBL17400680 | 0.94 | MPL (0.52) | MPLADORA3S1PR1ITGB2ICAM1 | |
| SCHEMBL18470814 | 0.94 | MPL (0.52) | MPLADORA3S1PR1ITGB2ICAM1 | |
| SCHEMBL17400670 | 0.93 | MPL (0.51) | MPLADORA3S1PR1ITGB2ICAM1 | |
| SCHEMBL17400713 | 0.93 | MPL (0.53) | MPLADORA3S1PR1ITGB2ICAM1 | |
| SCHEMBL17400506 | 0.92 | MPL (0.54) | MPLADORA3S1PR1ITGB2ICAM1 | |
| SCHEMBL17400571 | 0.92 | MPL (0.52) | MPLADORA3S1PR1ITGB2ICAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2963036-B1 | 2-ACYLAMINOTHIAZOLE DERIVATIVE AND SALT THEREOF | ASTELLAS PHARMA INC (JP) | 2019-08-28 | — | — | EP | disclosed |
| US-9562044-B2 | 2-acylaminothiazole derivative or salt thereof | ASTELLAS PHARMA INC. (JP) | 2017-02-07 | — | — | US | disclosed |
| EP-2963036-A1 | 2-ACYLAMINOTHIAZOLE DERIVATIVE AND SALT THEREOF | Astellas Pharma Inc. (JP) | 2016-01-06 | — | — | EP | disclosed |