Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 20/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1740139 | 1.00 | GCK (0.64) | GCK | |
| SCHEMBL1739615 | 0.92 | GCK (0.74) | GCK | |
| SCHEMBL3018145 | 0.92 | GCK (0.74) | GCK | |
| SCHEMBL1740007 | 0.89 | GCK (0.64) | GCK | |
| SCHEMBL1740015 | 0.89 | GCK (0.64) | GCK | |
| SCHEMBL1829271 | 0.88 | GCK (0.62) | GCK | |
| SCHEMBL1829276 | 0.88 | GCK (0.62) | GCK | |
| SCHEMBL2194811 | 0.86 | GCK (0.85) | GCK | |
| SCHEMBL2194817 | 0.86 | GCK (0.85) | GCK | |
| SCHEMBL1931104 | 0.84 | GCK (0.72) | GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8071606-B2 | Substituted pyrazinone amides useful for activation of glucokinase | PFIZER INC. (US) | 2011-12-06 | — | — | US | claimed |
| EP-2389374-A1 | SUBSTITUTED PYRAZINONE AMIDES | Pfizer Inc. (US) | 2011-11-30 | — | — | EP | claimed |
| US-20110254560-A1 | Electrical Systems and Battery Assemblies | KDT ACL INVESTMENTS, LLC | 2011-10-20 | — | — | US | claimed |
| WO-2010084428-A1 | SUBSTITUTED PYRAZINONE AMIDES | PFIZER INC. (US) | 2010-07-29 | — | — | WO | claimed |
| US-20100184777-A1 | Substituted Pyrazinone Amides | PFIZER INC | 2010-07-22 | — | — | US | claimed |
| US-8071606-B2 | Substituted pyrazinone amides useful for activation of glucokinase | PFIZER INC. (US) | 2011-12-06 | — | — | US | disclosed |
| US-8071606-B2 | Substituted pyrazinone amides useful for activation of glucokinase | PFIZER INC. (US) | 2011-12-06 | — | — | US | disclosed |
| US-8071606-B2 | Substituted pyrazinone amides useful for activation of glucokinase | PFIZER INC. (US) | 2011-12-06 | — | — | US | disclosed |
| WO-2010084428-A1 | SUBSTITUTED PYRAZINONE AMIDES | PFIZER INC. (US) | 2010-07-29 | — | — | WO | disclosed |
| US-20100184777-A1 | Substituted Pyrazinone Amides | PFIZER INC | 2010-07-22 | — | — | US | disclosed |
| US-20100184777-A1 | Substituted Pyrazinone Amides | PFIZER INC | 2010-07-22 | — | — | US | disclosed |
| US-20100184777-A1 | Substituted Pyrazinone Amides | PFIZER INC | 2010-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100184777-A1 | Substituted Pyrazinone Amides | GCK, GCKR, PDK2 | GCK 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.