Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 20/20 | 1.00 |
| ▸ | AKT2 | P31751 | 20/20 | 1.00 |
| ▸ | AKT3 | Q9Y243 | 20/20 | 1.00 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.71 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL192487 | 1.00 | AKT1 (1.00) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL190637 | 1.00 | AKT1 (1.00) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL191072 | 1.00 | AKT1 (1.00) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL1740271 | 1.00 | AKT1 (1.00) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL193013 | 0.95 | AKT1 (0.91) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL191437 | 0.95 | AKT1 (0.91) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL191436 | 0.95 | AKT1 (0.91) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL17424854 | 0.94 | AKT1 (0.89) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL190884 | 0.94 | AKT1 (0.89) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL193443 | 0.94 | AKT1 (0.89) | AKT1AKT2AKT3PIK3CAPRKG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2399909-A1 | Hydroxylated and methoxylated cyclopenta[d]pyrimidines as akt protein kinase inhibitors | Array Biopharma, Inc. (US) | 2011-12-28 | — | — | EP | disclosed |