Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | HTR2A | P28223 | 3/20 | 0.33 |
| ▸ | HTR2C | P28335 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL620429 | 0.89 | HTR2A (0.37) | LMNAMAPTNPSR1ALDH1A1PKM | |
| SCHEMBL1741916 | 0.86 | KMT2A (0.38) | MAPTNPSR1ALDH1A1PKMKMT2A | |
| SCHEMBL621315 | 0.77 | KMT2A (0.43) | PKMKMT2AHTR2AMEN1 | |
| SCHEMBL620404 | 0.64 | FGFR3 (0.47) | — | |
| SCHEMBL621993 | 0.63 | FGFR1 (0.39) | — | |
| SCHEMBL621994 | 0.63 | FGFR1 (0.41) | ALDH1A1GAA | |
| SCHEMBL3707718 | 0.63 | KMT2A (0.47) | MAPTNPSR1ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL2825482 | 0.63 | KMT2A (0.56) | LMNAALDH1A1PKMKMT2AHTR2A | |
| SCHEMBL15662656 | 0.63 | KCNH2 (0.38) | MAPTNPSR1ALDH1A1KMT2AMEN1 | |
| SCHEMBL3805548 | 0.62 | KCNH2 (0.42) | MAPTALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2389376-A1 | NOVEL BICYCLIC ANTIBIOTICS | Basilea Pharmaceutica AG (CH) | 2011-11-30 | — | — | EP | disclosed |
| WO-2010084152-A1 | NOVEL BICYCLIC ANTIBIOTICS | BASILEA PHARMACEUTICA AG (CH) | 2010-07-29 | — | — | WO | disclosed |