Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 20/20 | 0.56 |
| ▸ | JAK3 | P52333 | 20/20 | 0.56 |
| ▸ | JAK2 | O60674 | 11/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | SYK | P43405 | 1/20 | 0.51 |
| ▸ | TYK2 | P29597 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15390774 | 0.94 | JAK1 (0.55) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL1740785 | 0.86 | JAK1 (0.65) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL1740419 | 0.86 | JAK1 (0.65) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL340093 | 0.84 | JAK1 (0.55) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL340499 | 0.84 | JAK1 (0.55) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL29610592 | 0.84 | JAK1 (0.55) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL29609864 | 0.84 | JAK1 (0.55) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL1739612 | 0.84 | JAK1 (0.70) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL341376 | 0.84 | JAK1 (0.70) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL29610242 | 0.81 | JAK1 (0.57) | JAK1JAK3JAK2CYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2389372-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | Rigel Pharmaceuticals, Inc. (US) | 2011-11-30 | — | — | EP | claimed |
| US-8037782-B2 | Steering column assembly | FUJI KIKO CO., LTD. (JP) | 2011-10-18 | — | — | US | claimed |
| WO-2010085684-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS, INC. (US) | 2010-07-29 | — | — | WO | claimed |
| WO-2013173506-A2 | METHOD OF TREATING MUSCULAR DEGRADATION | RIGEL PHARMACEUTICALS, INC. (US) | 2013-11-21 | — | — | WO | disclosed |
| EP-2389372-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | Rigel Pharmaceuticals, Inc. (US) | 2011-11-30 | — | — | EP | disclosed |
| US-8037782-B2 | Steering column assembly | FUJI KIKO CO., LTD. (JP) | 2011-10-18 | — | — | US | disclosed |
| WO-2010085684-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS, INC. (US) | 2010-07-29 | — | — | WO | disclosed |