Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 16/20 | 0.50 |
| ▸ | JAK3 | P52333 | 12/20 | 0.50 |
| ▸ | AURKA | O14965 | 3/20 | 0.49 |
| ▸ | GRK6 | P43250 | 1/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.49 |
| ▸ | JAK1 | P23458 | 2/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | STK10 | O94804 | 1/20 | 0.49 |
| ▸ | PAK4 | O96013 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | FER | P16591 | 1/20 | 0.49 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | STAT3 | P40763 | 1/20 | 0.49 |
| ▸ | STAT5A | P42229 | 1/20 | 0.49 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL784005 | 0.92 | JAK2 (0.51) | JAK2JAK3AURKAGRK6NTRK1 | |
| SCHEMBL218986 | 0.83 | JAK2 (0.51) | JAK2JAK3AURKAGRK6NTRK1 | |
| SCHEMBL3349894 | 0.80 | JAK2 (0.75) | JAK2JAK3AURKANTRK1JAK1 | |
| SCHEMBL3349448 | 0.80 | JAK2 (0.75) | JAK2JAK3AURKAGRK6NTRK1 | |
| SCHEMBL3345053 | 0.80 | JAK2 (0.75) | JAK2JAK3AURKANTRK1JAK1 | |
| SCHEMBL219911 | 0.80 | JAK2 (0.75) | JAK2JAK3AURKANTRK1JAK1 | |
| SCHEMBL219307 | 0.79 | JAK2 (0.51) | JAK2JAK3AURKAGRK6NTRK1 | |
| SCHEMBL220186 | 0.78 | NTRK1 (0.51) | JAK2JAK3AURKAGRK6NTRK1 | |
| SCHEMBL24609025 | 0.74 | NTRK1 (0.51) | JAK2JAK3AURKAGRK6NTRK1 | |
| SCHEMBL588783 | 0.74 | JAK3 (0.57) | JAK2JAK3AURKAGRK6NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2388259-A1 | 4- (3-aminopyrazole) pyrimidine derivatives for use as tyrosine kinase inhibitors in the treatment of cancer | AstraZeneca AB (SE) | 2011-11-23 | — | — | EP | disclosed |
| US-8040733-B2 | Non-volatile memory device and method of operating the same | SAMSUNG ELECTRONICS CO., LTD. (KR) | 2011-10-18 | — | — | US | disclosed |