Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 3/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1741333 | 0.92 | KCNH2 (0.32) | MAP3K14LRRK2KCNH2S1PR1 | |
| SCHEMBL1740122 | 0.86 | SYK (0.35) | LRRK2KCNH2 | |
| SCHEMBL1740751 | 0.85 | PRKCQ (0.37) | MAP3K14LRRK2CHEK1 | |
| SCHEMBL1742251 | 0.79 | PRKCQ (0.46) | LRRK2CHEK1 | |
| SCHEMBL1739955 | 0.77 | LRRK2 (0.38) | MAP3K14LRRK2KCNH2CHEK1S1PR1 | |
| SCHEMBL1740853 | 0.77 | PRKCQ (0.48) | LRRK2 | |
| SCHEMBL1740730 | 0.76 | LRRK2 (0.41) | MAP3K14LRRK2KCNH2CHEK1S1PR1 | |
| SCHEMBL1742542 | 0.73 | PRKCQ (0.35) | MAP3K14LRRK2KCNH2 | |
| SCHEMBL1739732 | 0.71 | PRKCQ (0.44) | LRRK2CHEK1 | |
| SCHEMBL1740135 | 0.70 | PRKCQ (0.43) | LRRK2KCNH2CHEK1S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2389373-A1 | DERIVATIVES OF N2-(3-PYRIDIL OR PHENYL)-N4-(4-PIPERIDYL)-2,4-PYRIMIDINEDIAMINE USEFUL IN THE TREATMENT OF INFLAMMATORY, AUTOIMMUNE OR PROLIFERATIVE DISEASES | Rigel Pharmaceuticals, Inc. (US) | 2011-11-30 | — | — | EP | disclosed |
| US-20110253835-A1 | AIRCRAFT INTERIOR LAVATORY | BE INTELLECTUAL PROPERTY, INC. (US) | 2011-10-20 | — | — | US | disclosed |
| WO-2010090875-A1 | DERIVATIVES OF N2-(3-PYRIDIL OR PHENYL)-N4-(4-PIPERIDYL)-2,4-PYRIMIDINEDIAMINE USEFUL IN THE TREATMENT OF INFLAMMATORY, AUTOIMMUNE OR PROLIFERATIVE DISEASES | RIGEL PHARMACEUTICALS, INC. (US) | 2010-08-12 | — | — | WO | disclosed |