Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SAE1 | Q9UBE0 | 20/20 | 0.64 |
| ▸ | UBA2 | Q9UBT2 | 20/20 | 0.64 |
| ▸ | NAE1 | Q13564 | 14/20 | 0.64 |
| ▸ | UBA3 | Q8TBC4 | 14/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17410433 | 0.90 | SAE1 (0.68) | SAE1UBA2NAE1UBA3 | |
| SCHEMBL17421667 | 0.84 | SAE1 (0.76) | SAE1UBA2NAE1UBA3 | |
| SCHEMBL17421697 | 0.84 | SAE1 (0.75) | SAE1UBA2NAE1UBA3 | |
| SCHEMBL31372152 | 0.84 | SAE1 (0.75) | SAE1UBA2NAE1UBA3 | |
| SCHEMBL17398852 | 0.82 | SAE1 (0.73) | SAE1UBA2NAE1UBA3 | |
| SCHEMBL17410046 | 0.82 | SAE1 (0.78) | SAE1UBA2NAE1UBA3 | |
| SCHEMBL17429075 | 0.82 | SAE1 (0.58) | SAE1UBA2NAE1UBA3 | |
| SCHEMBL23192623 | 0.80 | SAE1 (0.69) | SAE1UBA2NAE1UBA3 | |
| SCHEMBL17410599 | 0.80 | SAE1 (0.85) | SAE1UBA2NAE1UBA3 | |
| SCHEMBL17398449 | 0.80 | SAE1 (0.78) | SAE1UBA2NAE1UBA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016004136-A1 | HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF SUMO ACTIVATING ENZYME | DUFFEY MATTHEW O (US) | 2016-01-07 | — | — | WO | disclosed |