Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 2/20 | 0.46 |
| ▸ | BCL6 | P41182 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 6/20 | 0.38 |
| ▸ | RET | P07949 | 4/20 | 0.38 |
| ▸ | KIF5B | P33176 | 4/20 | 0.38 |
| ▸ | ETV6 | P41212 | 4/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.38 |
| ▸ | CCDC6 | Q16204 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL431462 | 0.84 | KMT2A (0.58) | PRKCQBCL6KMT2AKDRRET | |
| Hydrochloric Acid SCHEMBL430133 | 0.83 | KMT2A (0.57) | PRKCQBCL6KMT2AKDRRET | |
| SCHEMBL1741322 | 0.82 | BCL6 (0.41) | PRKCQBCL6KMT2AKDRKCNH2 | |
| SCHEMBL27830729 | 0.79 | RET (0.49) | KDRRETKIF5BETV6KCNH2 | |
| SCHEMBL3497300 | 0.78 | PRKCQ (0.59) | PRKCQKDRAURKB | |
| SCHEMBL3495009 | 0.77 | PRKCQ (0.61) | PRKCQKDRFLT3TYRO3MERTK | |
| SCHEMBL3493194 | 0.77 | PRKCQ (0.61) | PRKCQKDRFLT3TYK2AURKB | |
| SCHEMBL3497767 | 0.76 | PRKCQ (0.62) | PRKCQKDRFLT3TYK2AURKB | |
| SCHEMBL3640879 | 0.75 | AXL (0.43) | KDRRETKIF5BETV6KCNH2 | |
| SCHEMBL3496512 | 0.75 | PRKCQ (0.59) | PRKCQBCL6KDRTYRO3MERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2389373-A1 | DERIVATIVES OF N2-(3-PYRIDIL OR PHENYL)-N4-(4-PIPERIDYL)-2,4-PYRIMIDINEDIAMINE USEFUL IN THE TREATMENT OF INFLAMMATORY, AUTOIMMUNE OR PROLIFERATIVE DISEASES | Rigel Pharmaceuticals, Inc. (US) | 2011-11-30 | — | — | EP | disclosed |
| US-20110253835-A1 | AIRCRAFT INTERIOR LAVATORY | BE INTELLECTUAL PROPERTY, INC. (US) | 2011-10-20 | — | — | US | disclosed |
| WO-2010090875-A1 | DERIVATIVES OF N2-(3-PYRIDIL OR PHENYL)-N4-(4-PIPERIDYL)-2,4-PYRIMIDINEDIAMINE USEFUL IN THE TREATMENT OF INFLAMMATORY, AUTOIMMUNE OR PROLIFERATIVE DISEASES | RIGEL PHARMACEUTICALS, INC. (US) | 2010-08-12 | — | — | WO | disclosed |