Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 19/20 | 0.79 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.57 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.57 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.57 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.57 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.57 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.57 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17354044 | 0.89 | MTOR (1.00) | MTORKCNH2PIK3CDPIK3CARICTOR | |
| SCHEMBL24044692 | 0.89 | MTOR (1.00) | MTORKCNH2PIK3CDPIK3CARICTOR | |
| SCHEMBL16023978 | 0.89 | MTOR (1.00) | MTORKCNH2PIK3CDPIK3CARICTOR | |
| SCHEMBL16023975 | 0.82 | MTOR (1.00) | MTORKCNH2PIK3CDPIK3CARICTOR | |
| SCHEMBL16023988 | 0.80 | MTOR (1.00) | MTORKCNH2PIK3CDPIK3CARICTOR | |
| SCHEMBL24044688 | 0.79 | MTOR (0.80) | MTORKCNH2PIK3CDPIK3CARICTOR | |
| SCHEMBL17354034 | 0.78 | MTOR (0.72) | MTOR | |
| SCHEMBL24044822 | 0.78 | MTOR (0.89) | MTORKCNH2PIK3CDPIK3CARPTOR | |
| SCHEMBL16023990 | 0.78 | MTOR (0.89) | MTORKCNH2PIK3CDPIK3CARPTOR | |
| SCHEMBL17353998 | 0.77 | MTOR (1.00) | MTORKCNH2PIK3CARICTORRPTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2966079-B1 | PYRIDOPYRIMIDINE OR PYRIMIDOPYRIMIDINE COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | SHANGHAI INST MATERIA MEDICA CAS (CN) | 2021-11-24 | — | — | EP | disclosed |
| EP-2966079-A1 | PYRIDOPYRIMIDINE OR PYRIMIDOPYRIMIDINE COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2016-01-13 | — | — | EP | disclosed |