Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 10/20 | 0.46 |
| ▸ | INSR | P06213 | 9/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 6/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.37 |
| ▸ | WEE1 | P30291 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16243440 | 1.00 | ALK (0.46) | ALKINSRAURKBPARP1KDR | |
| SCHEMBL17416609 | 0.92 | MEN1 (0.43) | ALKINSRAURKBPARP1AURKA | |
| SCHEMBL15156326 | 0.90 | ALK (0.47) | ALKINSRAURKBAURKAIRAK4 | |
| SCHEMBL16242933 | 0.90 | ALK (0.47) | ALKINSRAURKBAURKAIRAK4 | |
| SCHEMBL17416456 | 0.87 | PARP1 (0.39) | ALKINSRPARP1KDRAURKA | |
| SCHEMBL16243206 | 0.85 | ALK (0.48) | ALKINSRAURKBKDRIRAK4 | |
| SCHEMBL16243435 | 0.84 | ALK (0.63) | ALKINSRAURKBKDRAURKA | |
| SCHEMBL16243097 | 0.83 | ALK (0.56) | ALKINSRAURKBPARP1KDR | |
| SCHEMBL16242972 | 0.83 | ALK (0.60) | ALKINSRAURKBPARP1KDR | |
| SCHEMBL15172549 | 0.83 | ALK (0.61) | ALKINSRAURKBKDRAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2809671-B1 | IMIDAZO [4, 5 - B]PYRIDINE DERIVATIVES AS ALK AND JAK MODULATORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | CEPHALON INC (US) | 2016-01-13 | — | — | EP | disclosed |