⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1742347 | 0.83 | — | — | |
| SCHEMBL3364316 | 0.80 | — | — | |
| SCHEMBL3694046 | 0.78 | — | — | |
| SCHEMBL388062 | 0.78 | — | — | |
| SCHEMBL12696676 | 0.78 | — | — | |
| SCHEMBL15710841 | 0.78 | — | — | |
| SCHEMBL27487832 | 0.78 | — | — | |
| SCHEMBL10519913 | 0.78 | SSTR4 (0.38) | — | |
| SCHEMBL11172145 | 0.77 | SSTR4 (0.36) | — | |
| SCHEMBL8898373 | 0.77 | SSTR4 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2389371-A2 | BUMETANIDE, FUROSEMIDE, PIRETANIDE, AZOSEMIDE, AND TORSEMIDE ANALOGS, COMPOSITIONS AND METHODS OF USE | Neurotherapeutics Pharma, Inc. (US) | 2011-11-30 | — | — | EP | disclosed |
| US-7820656-B2 | Pharmaceutical composition comprising N-aryl N′ morpholino/piperidino thiocarbamide derivatives for treating type II diabetes | Kim, Sung-jin (KR) | 2010-10-26 | — | — | US | disclosed |
| WO-2010085352-A2 | BUMETANIDE, FUROSEMIDE, PIRETANIDE, AZOSEMIDE, AND TORSEMIDE ANALOGS, COMPOSITIONS AND METHODS OF USE | NEUROTHERAPEUTICS PHARMA, INC. (US) | 2010-07-29 | — | — | WO | disclosed |
| US-20060142285-A1 | Pharmaceutical composition comprising N-aryl N' morpholino/piperidino thiocarbamide derivatives for treating and preventing diabetes, diabetic complications, insulin resistance and insulin resistance syndrome | KIM SUNG-JIN | 2006-06-29 | — | — | US | disclosed |
| EP-0674513-A4 | — | — | 1995-10-25 | — | — | EP | disclosed |
| EP-0674513-A1 | RETROVIRAL PROTEASE INHIBITING COMPOUNDS. | ABBOTT LAB (US) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994014436-A1 | RETROVIRAL PROTEASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1994-07-07 | — | — | WO | disclosed |
| US-4275014-A | SULFUR VULCANIZABLE RUBBERS | PENNWALT CORPORATION (US) | 1981-06-23 | — | — | US | disclosed |
| US-4220589-A | N-(Oxazolidinothio) imides that provide scorch retardant nonblooming elastomeric compositions | PENNWALT CORPORATION (US) | 1980-09-02 | — | — | US | disclosed |
| US-4006140-A | AGING RESISTANCE IMPROVERS FOR VULCANIZABLE RUBBERS | THE B. F. GOODRICH COMPANY (US) | 1977-02-01 | — | — | US | disclosed |