Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 17/20 | 0.57 |
| ▸ | TNK1 | Q13470 | 3/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL709688 | 0.97 | PARP1 (0.60) | PARP1TNK1NTRK1KDM4EMEN1 | |
| SCHEMBL709469 | 0.95 | PARP1 (0.61) | PARP1TNK1NTRK1KDM4EMEN1 | |
| SCHEMBL1738902 | 0.92 | PARP1 (0.60) | PARP1TNK1NTRK1TNK2 | |
| SCHEMBL1742000 | 0.92 | PARP1 (0.49) | PARP1TNK1NTRK1KDM4EMEN1 | |
| SCHEMBL716551 | 0.89 | PARP1 (0.51) | PARP1TNK1NTRK1KDM4EMEN1 | |
| SCHEMBL708332 | 0.89 | PARP1 (0.63) | PARP1TNK1NTRK1TNK2 | |
| SCHEMBL707608 | 0.89 | PARP1 (0.59) | PARP1TNK1NTRK1KDM4EMEN1 | |
| SCHEMBL1742046 | 0.88 | PARP1 (0.48) | PARP1NTRK1KDM4EMEN1ALDH1A1 | |
| SCHEMBL1741938 | 0.88 | PARP1 (0.55) | PARP1KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL708165 | 0.87 | PARP1 (0.61) | PARP1TNK1NTRK1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2389379-A1 | Poly (ADP-Ribose) Polymerase (PARP) Inhibitors | Takeda Pharmaceutical Company Limited (JP) | 2011-11-30 | — | — | EP | disclosed |