Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 15/20 | 0.59 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.34 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SCN1A | P35498 | 1/20 | 0.32 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.32 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15543440 | 0.86 | SCN9A (0.68) | SCN9AFFAR4SCN5ASCN7ASCN1A | |
| SCHEMBL17428627 | 0.83 | SCN9A (0.67) | SCN9AFFAR4SCN5ASCN7ASCN1A | |
| SCHEMBL21075477 | 0.81 | SCN9A (0.69) | SCN9AFFAR4SCN5ASCN7A | |
| SCHEMBL15599056 | 0.81 | SCN9A (0.64) | SCN9AFFAR4SCN5ASCN7ASCN1A | |
| SCHEMBL17423164 | 0.79 | SCN9A (0.64) | SCN9ASCN5ASCN7A | |
| SCHEMBL17428454 | 0.79 | SCN9A (0.64) | SCN9ASCN5ASCN7A | |
| SCHEMBL19064841 | 0.79 | SCN9A (0.59) | SCN9AFFAR4SCN5ASCN7ASCN1A | |
| SCHEMBL19430740 | 0.79 | SCN9A (0.68) | SCN9AFFAR4SCN5ASCN7A | |
| SCHEMBL20680118 | 0.78 | SCN9A (0.64) | SCN9AFFAR4SCN5ASCN7A | |
| SCHEMBL21075815 | 0.78 | SCN9A (0.64) | SCN9AFFAR4SCN5ASCN7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3166939-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | Genentech, Inc. (US) | 2017-05-17 | — | — | EP | disclosed |
| WO-2016007534-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2016-01-14 | — | — | WO | disclosed |