Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN7A | Q01118 | 9/20 | 0.50 |
| ▸ | SCN5A | Q14524 | 8/20 | 0.50 |
| ▸ | SCN9A | Q15858 | 14/20 | 0.49 |
| ▸ | SCN1A | P35498 | 2/20 | 0.42 |
| ▸ | SCN4A | P35499 | 2/20 | 0.42 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.42 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.42 |
| ▸ | SCN2B | O60939 | 1/20 | 0.42 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.42 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL17423168 | 0.90 | SCN9A (0.53) | SCN7ASCN5ASCN9ASCN1ASCN4A | |
| SCHEMBL17423187 | 0.83 | SCN7A (0.54) | SCN7ASCN5ASCN9ASCN1ASCN4A | |
| SCHEMBL20680073 | 0.83 | SCN7A (0.54) | SCN7ASCN5ASCN9ASCN1ASCN4A | |
| SCHEMBL17423068 | 0.80 | SCN7A (0.62) | SCN7ASCN5ASCN9ASCN1ASCN4A | |
| SCHEMBL17422986 | 0.80 | SCN7A (0.62) | SCN7ASCN5ASCN9ASCN1ASCN4A | |
| SCHEMBL17423132 | 0.80 | SCN9A (0.71) | SCN7ASCN5ASCN9ASCN1ASCN4A | |
| SCHEMBL21075198 | 0.79 | SCN7A (0.58) | SCN7ASCN5ASCN9ASCN1ASCN4A | |
| SCHEMBL19083861 | 0.79 | SCN7A (0.58) | SCN7ASCN5ASCN9ASCN1ASCN4A | |
| SCHEMBL17428583 | 0.79 | SCN9A (0.63) | SCN7ASCN5ASCN9ASCN1ASCN4A | |
| SCHEMBL19064826 | 0.79 | SCN9A (0.63) | SCN7ASCN5ASCN9ASCN1ASCN4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3166939-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | Genentech, Inc. (US) | 2017-05-17 | — | — | EP | disclosed |
| WO-2016007534-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2016-01-14 | — | — | WO | disclosed |