Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | F7 | P08709 | 1/20 | 0.54 |
| ▸ | F3 | P13726 | 1/20 | 0.54 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MITF | O75030 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PYGL | P06737 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HAT1 | O14929 | 2/20 | 0.43 |
| ▸ | EP300 | Q09472 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13533538 | 0.87 | NR4A2 (0.64) | MAPTNR4A2LMNARAB9AALDH1A1 | |
| SCHEMBL3443344 | 0.87 | F7 (0.73) | MAPTNR4A2LMNARAB9AALDH1A1 | |
| SCHEMBL30392504 | 0.84 | F7 (0.74) | NR4A2LMNAALDH1A1MAPK1F7 | |
| SCHEMBL613332 | 0.84 | F7 (0.74) | NR4A2LMNAALDH1A1MAPK1F7 | |
| SCHEMBL3195663 | 0.83 | NR4A2 (0.59) | MAPTNR4A2LMNARAB9AALDH1A1 | |
| SCHEMBL28709470 | 0.83 | NR4A2 (0.56) | MAPTNR4A2LMNARAB9AALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL4556453 | 0.83 | F7 (0.72) | NR4A2LMNAALDH1A1MAPK1F7 | |
| SCHEMBL30275070 | 0.82 | MAPT (0.62) | MAPTLMNARAB9AGPR84MEN1 | |
| SCHEMBL26204498 | 0.81 | NR4A2 (0.65) | MAPTNR4A2ALDH1A1F7F3 | |
| SCHEMBL3182218 | 0.81 | NR4A2 (0.69) | MAPTNR4A2ALDH1A1F7F3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016007837-A1 | CARBONYL LINKED BICYCLIC HETEROARYL ANTIBIOTIC TOLERANCE INHIBITORS | SPERO THERAPEUTICS, INC. (US) | 2016-01-14 | — | — | WO | disclosed |
| WO-2016007837-A1 | CARBONYL LINKED BICYCLIC HETEROARYL ANTIBIOTIC TOLERANCE INHIBITORS | SPERO THERAPEUTICS, INC. (US) | 2016-01-14 | — | — | WO | disclosed |