Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 9/20 | 0.50 |
| ▸ | ACVRL1 | P37023 | 9/20 | 0.50 |
| ▸ | RET | P07949 | 4/20 | 0.50 |
| ▸ | ROS1 | P08922 | 4/20 | 0.50 |
| ▸ | MET | P08581 | 2/20 | 0.50 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.43 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.43 |
| ▸ | IGF1R | P08069 | 11/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3459244 | 0.90 | NTRK1 (0.60) | NTRK1ACVRL1RETROS1MET | |
| SCHEMBL441092 | 0.90 | NTRK1 (0.60) | NTRK1ACVRL1RETROS1MET | |
| SCHEMBL16440373 | 0.87 | NTRK1 (0.60) | NTRK1ACVRL1RETROS1MET | |
| SCHEMBL469150 | 0.87 | NTRK1 (0.60) | NTRK1ACVRL1RETROS1MET | |
| SCHEMBL469163 | 0.87 | NTRK1 (0.60) | NTRK1ACVRL1RETROS1MET | |
| SCHEMBL439732 | 0.83 | NTRK1 (0.69) | NTRK1ACVRL1RETROS1MET | |
| SCHEMBL16437782 | 0.83 | NTRK1 (0.69) | NTRK1ACVRL1RETROS1MET | |
| SCHEMBL441648 | 0.79 | NTRK1 (0.61) | NTRK1ACVRL1RETROS1MET | |
| SCHEMBL441500 | 0.77 | NTRK1 (0.71) | NTRK1ACVRL1RETROS1MET | |
| SCHEMBL441109 | 0.77 | NTRK1 (0.68) | NTRK1ACVRL1RETROS1MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2966076-A1 | NOVEL TYROSINE KINASE INHIBITORS | ChemBridge Corporation (US) | 2016-01-13 | — | — | EP | disclosed |