Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 19/20 | 0.80 |
| ▸ | TP53 | P04637 | 9/20 | 0.80 |
| ▸ | THRB | P10828 | 3/20 | 0.80 |
| ▸ | LMNA | P02545 | 9/20 | 0.67 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3324538 | 0.91 | MAPT (0.66) | MAPTTP53THRBLMNAPOLB | |
| SCHEMBL3324506 | 0.85 | MAPT (0.61) | MAPTTP53THRBLMNAPOLB | |
| SCHEMBL3321687 | 0.79 | MAPT (0.81) | MAPTTP53THRBLMNAPOLB | |
| SCHEMBL3323179 | 0.79 | MAPT (0.50) | MAPTTP53THRBLMNA | |
| SCHEMBL3324225 | 0.79 | MAPT (0.79) | MAPTTP53THRBLMNAPOLB | |
| SCHEMBL3321679 | 0.78 | MAPT (0.78) | MAPTTP53THRBLMNAPOLB | |
| SCHEMBL3324252 | 0.76 | MAPT (0.75) | MAPTTP53THRBLMNA | |
| SCHEMBL3325888 | 0.75 | MAPT (0.73) | MAPTTP53THRBLMNAPOLB | |
| SCHEMBL3322966 | 0.74 | MAPT (0.72) | MAPTTP53THRBLMNAPOLB | |
| SCHEMBL3323549 | 0.74 | MAPT (0.75) | MAPTTP53THRBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139472-B1 | TETRAHYDROINDOLE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GENKYOTEX SA (CH) | 2016-01-13 | — | — | EP | disclosed |