Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 11/20 | 0.74 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.74 |
| ▸ | PLK4 | O00444 | 3/20 | 0.74 |
| ▸ | AURKA | O14965 | 3/20 | 0.74 |
| ▸ | RET | P07949 | 3/20 | 0.74 |
| ▸ | FLT3 | P36888 | 3/20 | 0.74 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.74 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.74 |
| ▸ | MST1R | Q04912 | 3/20 | 0.74 |
| ▸ | IKBKE | Q14164 | 3/20 | 0.74 |
| ▸ | STK16 | O75716 | 2/20 | 0.74 |
| ▸ | TNK1 | Q13470 | 2/20 | 0.74 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.74 |
| ▸ | ADCK1 | Q86TW2 | 2/20 | 0.74 |
| ▸ | PIP4K2C | Q8TBX8 | 2/20 | 0.74 |
| ▸ | NEK9 | Q8TD19 | 2/20 | 0.74 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.74 |
| ▸ | IRAK3 | Q9Y616 | 2/20 | 0.74 |
| ▸ | LATS1 | O95835 | 1/20 | 0.74 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17425860 | 0.92 | SYK (0.83) | SYKPTK2PLK4AURKARET | |
| SCHEMBL2627484 | 0.89 | SYK (0.84) | SYKPTK2PLK4AURKARET | |
| SCHEMBL13451897 | 0.88 | SYK (0.84) | SYKPTK2PLK4AURKARET | |
| SCHEMBL16856483 | 0.88 | SYK (0.77) | SYKPTK2PLK4AURKARET | |
| SCHEMBL26738117 | 0.88 | SYK (0.76) | SYKPTK2PLK4AURKARET | |
| SCHEMBL2627481 | 0.87 | SYK (0.82) | SYKPTK2PLK4AURKARET | |
| SCHEMBL16682499 | 0.87 | SYK (0.80) | SYKPTK2PLK4AURKARET | |
| SCHEMBL16820329 | 0.87 | SYK (0.89) | SYKPTK2PLK4AURKARET | |
| SCHEMBL20006821 | 0.87 | SYK (0.82) | SYKPTK2PLK4AURKARET | |
| SCHEMBL4108129 | 0.86 | SYK (0.81) | SYKPTK2PLK4AURKARET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2448950-B1 | SYNTHESIS OF N4-(2,2-DIMETHYL-4-[(DIHYDROGEN PHOSPHONOXY)METHYL]-3-OXO-5-PYRIDO[1,4]OXAZIN-6-YL)-5-FLUORO-N2-(3,4,5-TRIMETHOXYPHENYL)-2,4-PYRIMIDINEDIAMINE DISODIUM SALT | RIGEL PHARMACEUTICALS INC (US) | 2016-01-13 | — | — | EP | disclosed |