Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 17/20 | 0.38 |
| ▸ | JAK2 | O60674 | 3/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | LYN | P07948 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | TEC | P42680 | 1/20 | 0.36 |
| ▸ | TXK | P42681 | 1/20 | 0.36 |
| ▸ | BMX | P51813 | 1/20 | 0.36 |
| ▸ | ITK | Q08881 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17425875 | 0.95 | SCN9A (0.35) | BTKJAK2LCKLYNKIT | |
| SCHEMBL9983687 | 0.92 | BTK (0.38) | BTKJAK2LCKLYNKIT | |
| SCHEMBL9982693 | 0.87 | JAK2 (0.41) | BTKJAK2LCKLYNKIT | |
| SCHEMBL9983464 | 0.87 | BTK (0.35) | BTKJAK2LCKLYNKIT | |
| SCHEMBL14860110 | 0.85 | BTK (0.34) | BTKJAK2LCKLYNKIT | |
| SCHEMBL17425889 | 0.83 | BTK (0.36) | BTKJAK2LCKLYNKIT | |
| SCHEMBL9983728 | 0.82 | KDM4E (0.39) | BTKJAK2 | |
| SCHEMBL9983329 | 0.82 | KIT (0.40) | BTKJAK2KIT | |
| SCHEMBL9983901 | 0.80 | TP53 (0.40) | BTKKIT | |
| SCHEMBL9983764 | 0.80 | BTK (0.43) | BTKJAK2LCKLYNKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2582668-B1 | CARBOLINE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2016-01-13 | — | — | EP | disclosed |