Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLLT1 | Q03111 | 14/20 | 0.44 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.42 |
| ▸ | MLLT3 | P42568 | 4/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
| ▸ | YEATS2 | Q9ULM3 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6813380 | 0.81 | MLLT1 (0.58) | MLLT1DNMT1MLLT3SCN5AYEATS2 | |
| SCHEMBL252922 | 0.69 | PIK3CG (0.47) | MLLT1DNMT1MLLT3SCN5AMAPK14 | |
| SCHEMBL24816112 | 0.69 | DNMT1 (0.46) | MLLT1DNMT1MLLT3SCN5AYEATS2 | |
| SCHEMBL23432690 | 0.68 | MLLT1 (0.49) | MLLT1DNMT1MLLT3SCN5AYEATS2 | |
| SCHEMBL25124502 | 0.67 | MLLT1 (0.46) | MLLT1DNMT1MLLT3SCN5AYEATS2 | |
| SCHEMBL11474506 | 0.64 | SCN5A (0.58) | MLLT1DNMT1SCN5AMAPK14TGFBR1 | |
| SCHEMBL24783499 | 0.63 | MLLT1 (0.45) | MLLT1DNMT1MLLT3SCN5AYEATS2 | |
| SCHEMBL23230446 | 0.63 | DNMT1 (0.41) | MLLT1DNMT1MLLT3SCN5AYEATS2 | |
| SCHEMBL38659050 | 0.62 | MLLT1 (0.76) | MLLT1MLLT3YEATS2NAMPT | |
| SCHEMBL23686714 | 0.61 | DNMT1 (0.39) | MLLT1DNMT1MLLT3SCN5AMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2802577-B1 | TRIAZOLYL-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-03-01 | — | — | EP | disclosed |
| EP-2966075-A1 | CERTAIN TRIAZOLOPYRIDINES, COMPOSITIONS THEREOF AND THEIR USE IN THE TREATMENT OF CANCER. | Hutchison Medipharma Limited (CN) | 2016-01-13 | — | — | EP | disclosed |