Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 20/20 | 0.71 |
| ▸ | NTRK1 | P04629 | 17/20 | 0.63 |
| ▸ | PAK4 | O96013 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30297816 | 0.88 | PLK4 (0.66) | PLK4NTRK1PAK4 | |
| SCHEMBL22054994 | 0.83 | PLK4 (0.54) | PLK4NTRK1PAK4 | |
| SCHEMBL26505011 | 0.81 | PLK4 (0.50) | PLK4NTRK1PAK4 | |
| SCHEMBL30297955 | 0.81 | PLK4 (0.50) | PLK4NTRK1PAK4 | |
| SCHEMBL23878754 | 0.81 | PLK4 (0.49) | PLK4NTRK1PAK4 | |
| SCHEMBL174824 | 0.79 | PLK4 (0.63) | PLK4NTRK1PAK4 | |
| SCHEMBL29227691 | 0.79 | PLK4 (0.51) | PLK4NTRK1PAK4 | |
| SCHEMBL174354 | 0.79 | PLK4 (0.50) | PLK4NTRK1PAK4 | |
| SCHEMBL22054255 | 0.79 | PLK4 (0.67) | PLK4NTRK1PAK4 | |
| SCHEMBL174456 | 0.77 | PLK4 (0.59) | PLK4NTRK1PAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118126043-B | PLK4 inhibitor with high selectivity and preparation method and application thereof | 沈阳药科大学 | 2025-01-28 | — | — | CN | disclosed |
| WO-2024114574-A1 | HIGH-SELECTIVITY PLK4 INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 沈阳药科大学 | 2024-06-06 | — | — | WO | disclosed |
| CN-118126043-A | PLK4 inhibitor with high selectivity and preparation method and application thereof | 沈阳药科大学 | 2024-06-04 | — | — | CN | disclosed |
| CN-116023380-B | Pyrazolopyrimidine derivative, and preparation method and application thereof | 沈阳药科大学 | 2024-01-23 | — | — | CN | disclosed |
| WO-2023071218-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 沈阳药科大学 | 2023-05-04 | — | — | WO | disclosed |
| CN-116023380-A | Pyrazolopyrimidine derivative, and preparation method and application thereof | 沈阳药科大学 | 2023-04-28 | — | — | CN | disclosed |
| US-20130303533-A1 | AZOLOPYRIDINE AND AZOLOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2013-11-14 | — | — | US | disclosed |
| EP-2611809-A1 | AZOLOPYRIDINE AND AZOLOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030924-A1 | AZOLOPYRIDINE AND AZOLOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2012-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130303533-A1 | AZOLOPYRIDINE AND AZOLOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | JAK3, JAK2, JAK1 | PLK4 246/4885NTRK1 1619/4885PAK4 784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.