Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | IAPP | P10997 | 3/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.41 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | FDPS | P14324 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 3/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19263832 | 0.82 | GLA (0.57) | GLATDP1IAPPPTGS1PTGS2 | |
| SCHEMBL1359335 | 0.78 | GLA (0.77) | GLATDP1IAPPPTGS1PTGS2 | |
| SCHEMBL1359336 | 0.78 | GLA (0.77) | GLATDP1IAPPPTGS1PTGS2 | |
| SCHEMBL9353385 | 0.77 | TDP1 (0.59) | GLATDP1IAPPPTGS1PTGS2 | |
| SCHEMBL9353382 | 0.77 | TDP1 (0.59) | GLATDP1IAPPPTGS1PTGS2 | |
| SCHEMBL28791431 | 0.77 | HDAC8 (0.59) | GLATDP1IAPPPTGS1PTGS2 | |
| SCHEMBL1909363 | 0.77 | HDAC8 (0.59) | GLATDP1IAPPPTGS1PTGS2 | |
| SCHEMBL7992528 | 0.77 | CTBP2 (0.46) | TDP1RAB9AKMT2A | |
| SCHEMBL1245524 | 0.74 | CES1 (0.52) | PTGS1AKR1B1HDAC6KMT2AHDAC8 | |
| SCHEMBL11810722 | 0.74 | CES1 (0.52) | PTGS1AKR1B1HDAC6KMT2AHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9718837-B2 | Nitrogen-containing heterocyclic ring substituted dihydroartemisinin derivatives and use thereof | SHENYANG PHARMACEUTICAL UNIVERSITY (CN) | 2017-08-01 | — | — | US | disclosed |
| US-9718837-B2 | Nitrogen-containing heterocyclic ring substituted dihydroartemisinin derivatives and use thereof | SHENYANG PHARMACEUTICAL UNIVERSITY (CN) | 2017-08-01 | — | — | US | disclosed |
| US-20160009729-A1 | NITROGEN-CONTAINING HETEROCYCLIC RING SUBSTITUTED DIHYDROARTEMISININ DERIVATIVES AND USE THEREOF | SHENYANG PHARMACEUTICAL UNIVERSITY (CN) | 2016-01-14 | — | — | US | disclosed |
| US-20160009729-A1 | NITROGEN-CONTAINING HETEROCYCLIC RING SUBSTITUTED DIHYDROARTEMISININ DERIVATIVES AND USE THEREOF | SHENYANG PHARMACEUTICAL UNIVERSITY (CN) | 2016-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160009729-A1 | NITROGEN-CONTAINING HETEROCYCLIC RING SUBSTITUTED DIHYDROARTEMISININ DERIVATIVES AND USE THEREOF | DHODH, NQO2, DPYD | GLA 3803/4885TDP1 4694/4885IAPP 4623/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.