Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTK | P29376 | 3/20 | 0.53 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.53 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.53 |
| ▸ | RET | P07949 | 2/20 | 0.53 |
| ▸ | MST1R | Q04912 | 2/20 | 0.53 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.53 |
| ▸ | MET | P08581 | 1/20 | 0.53 |
| ▸ | GRK5 | P34947 | 1/20 | 0.53 |
| ▸ | CDK8 | P49336 | 1/20 | 0.53 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.53 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.52 |
| ▸ | KDR | P35968 | 2/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | PRKACA | P17612 | 1/20 | 0.52 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17403264 | 0.78 | LTK (0.44) | LTKDYRK1BALKRETMST1R | |
| SCHEMBL13824876 | 0.76 | CHEK1 (0.62) | LTKDYRK1BALKRETMST1R | |
| SCHEMBL1855620 | 0.74 | LTK (0.60) | LTKDYRK1BALKRETMST1R | |
| SCHEMBL17408735 | 0.73 | LTK (0.58) | LTKDYRK1BALKRETMST1R | |
| SCHEMBL20775937 | 0.73 | LTK (0.58) | LTKDYRK1BALKRETMST1R | |
| SCHEMBL20772869 | 0.73 | LTK (0.58) | LTKDYRK1BALKRETMST1R | |
| SCHEMBL1585160 | 0.73 | CLK4 (0.58) | LTKDYRK1BALKRETMST1R | |
| SCHEMBL17403245 | 0.72 | LTK (0.47) | LTKDYRK1BALKRETMST1R | |
| SCHEMBL24665999 | 0.72 | LTK (0.54) | LTKDYRK1BALKRETMST1R | |
| SCHEMBL17403241 | 0.71 | LTK (0.46) | LTKDYRK1BALKRETMST1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016005330-A1 | DIHYDROPYRIDOPYRAZINE-1,8-DIONES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF VIRAL DISEASES | F. HOFFMANN-LA ROCHE AG (CH) | 2016-01-14 | — | — | WO | disclosed |