Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 17/20 | 0.62 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.55 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.55 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5550559 | 0.90 | IL2 (0.61) | IL2STIM1ORAI1ORAI2MEN1 | |
| SCHEMBL5554240 | 0.89 | IL2 (0.62) | IL2STIM1ORAI1ORAI2 | |
| SCHEMBL15395771 | 0.88 | IL2 (0.65) | IL2STIM1ORAI1ORAI2MEN1 | |
| SCHEMBL7927446 | 0.86 | IL2 (0.63) | IL2STIM1ORAI1ORAI2MEN1 | |
| SCHEMBL7932421 | 0.86 | IL2 (0.63) | IL2STIM1ORAI1ORAI2MEN1 | |
| SCHEMBL5554192 | 0.85 | STIM1 (0.57) | IL2STIM1ORAI1ORAI2MEN1 | |
| SCHEMBL5555347 | 0.84 | IL2 (0.55) | IL2STIM1ORAI1ORAI2 | |
| SCHEMBL5554329 | 0.84 | IL2 (0.56) | IL2STIM1ORAI1ORAI2 | |
| SCHEMBL15395847 | 0.82 | IL2 (0.59) | IL2STIM1ORAI1ORAI2MEN1 | |
| SCHEMBL15395968 | 0.82 | IL2 (0.59) | IL2STIM1ORAI1ORAI2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848435-B1 | COMPOUNDS AGAINST INFLAMMATIONS AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP (US) | 2016-01-20 | — | — | EP | disclosed |