Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 17/20 | 0.44 |
| ▸ | HTR2B | P41595 | 15/20 | 0.44 |
| ▸ | HTR2A | P28223 | 14/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HTR5A | P47898 | 1/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2019169 | 0.77 | HTR2C (0.45) | HTR2CHTR2BHTR2AHTR6HTR3E | |
| SCHEMBL2016949 | 0.67 | HTR2C (0.45) | HTR2CHTR2BHTR2AHTR6CYP2D6 | |
| SCHEMBL2020031 | 0.67 | HTR2C (0.42) | HTR2CHTR2BHTR2AHTR6 | |
| SCHEMBL5322262 | 0.66 | HTR2C (0.73) | HTR2CHTR2BHTR2AHTR6DRD2 | |
| SCHEMBL1366067 | 0.66 | HTR2C (0.73) | HTR2CHTR2BHTR2AHTR6DRD2 | |
| SCHEMBL692674 | 0.65 | HTR2C (0.51) | HTR2CHTR2BHTR2ADRD2 | |
| SCHEMBL693673 | 0.65 | HTR2C (0.51) | HTR2CHTR2BHTR2AHTR6DRD2 | |
| SCHEMBL2014604 | 0.65 | HTR2C (0.51) | HTR2CHTR2BHTR2AHTR6DRD2 | |
| SCHEMBL2020227 | 0.62 | HTR2C (0.44) | HTR2CHTR2BHTR2AHTR6 | |
| SCHEMBL5458025 | 0.62 | HTR2C (1.00) | HTR2CHTR2BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2522671-B1 | Modulators of 5-HT receptors and methods of use thereof | ABBVIE INC (US) | 2016-01-20 | — | — | EP | disclosed |