Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.55 |
| ▸ | CDK4 | P11802 | 6/20 | 0.36 |
| ▸ | CCND1 | P24385 | 6/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | QDPR | P09417 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1743580 | 1.00 | IDO1 (0.55) | IDO1CDK4CCND1DRD2DRD3 | |
| SCHEMBL1743577 | 1.00 | IDO1 (0.55) | IDO1CDK4CCND1DRD2DRD3 | |
| SCHEMBL6558377 | 1.00 | IDO1 (0.55) | IDO1CDK4CCND1DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL6556581 | 0.99 | IDO1 (0.54) | IDO1CDK4CCND1DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL6556575 | 0.99 | IDO1 (0.54) | IDO1CDK4CCND1DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL6556570 | 0.99 | IDO1 (0.54) | IDO1CDK4CCND1DRD2DRD3 | |
| SCHEMBL6556426 | 0.90 | IDO1 (0.58) | IDO1PDE4DPDCD1CD274ALDH1A1 | |
| SCHEMBL6556422 | 0.90 | IDO1 (0.58) | IDO1PDE4DPDCD1CD274ALDH1A1 | |
| SCHEMBL6556416 | 0.90 | IDO1 (0.58) | IDO1PDE4DPDCD1CD274ALDH1A1 | |
| SCHEMBL6556322 | 0.88 | IDO1 (0.41) | IDO1CDK4CCND1DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958285-B1 | TRICYCLIC BENZO[e]ISOINDOLES AND BENZO[h]ISOQUINOLINES | HOFFMANN LA ROCHE (CH) | 2004-01-07 | — | — | EP | claimed |
| US-9730945-B2 | Diagnosis of autism spectrum disorders and its treatment with an antagonist or inhibitor of the 5-HT2c receptor signaling pathway | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2017-08-15 | — | — | US | disclosed |
| US-20150126496-A1 | DIAGNOSIS AND TREATMENT OF AUTISM SPECTRUM DISORDERS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2015-05-07 | — | — | US | disclosed |
| US-8940732-B2 | Diagnosis of autism spectrum disorders and its treatment with an antagonist or inhibitor of the 5-HT2c receptor signaling pathway | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2015-01-27 | — | — | US | disclosed |
| WO-2012149472-A2 | METHODS, COMPOSITIONS, AND KITS FOR TREATING AND PREVENTING NEUROLOGICAL CONDITIONS | IGNITE INSTITUTE FOR INDIVIDUALIZED HEALTH (US) | 2012-11-01 | — | — | WO | disclosed |
| EP-2387611-A1 | DIAGNOSIS AND TREATMENT OF AUTISM SPECTRUM DISORDERS | Massachusetts Institute of Technology (US) | 2011-11-23 | — | — | EP | disclosed |
| US-8040693-B2 | Universal expandable patch panel bracket | PANDUIT CORP. (US) | 2011-10-18 | — | — | US | disclosed |
| US-20100298304-A1 | DIAGNOSIS AND TREATMENT OF AUTISM SPECTRUM DISORDERS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2010-11-25 | — | — | US | disclosed |
| WO-2010083044-A1 | DIAGNOSIS AND TREATMENT OF AUTISM SPECTRUM DISORDERS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2010-07-22 | — | — | WO | disclosed |
| EP-0958285-B1 | TRICYCLIC BENZO[e]ISOINDOLES AND BENZO[h]ISOQUINOLINES | HOFFMANN LA ROCHE (CH) | 2004-01-07 | — | — | EP | disclosed |
| US-6310208-B1 | Serotonin receptor binding benzo[e]isoindoles and benzo[h]isoquinolines | HOFFMANN-LA ROCHE INC. | 2001-10-30 | — | — | US | disclosed |