SCHEMBL1743705

SCHEMBL1743705

COc1ccc(CN(c2ncns2)S(=O)(=O)c2ccc(Oc3cc(F)c(Cl)cc3-c3cnn(C(=O)O)c3)c(C#N)c2)c(OC)c1

nearest known ligand 0.47

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 18/20 0.47
SLC22A12 Q96S37 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1094482 0.93 SCN9A (0.45) SCN9ASLC22A12
SCHEMBL3478328 0.89 SCN9A (0.42) SCN9ASLC22A12
SCHEMBL9923652 0.88 SCN9A (0.44) SCN9ASLC22A12
SCHEMBL1095406 0.83 SCN9A (0.43) SCN9ASLC22A12
SCHEMBL1093952 0.80 SCN9A (0.61) SCN9A
SCHEMBL31093304 0.78 SCN9A (0.45) SCN9ASLC22A12
SCHEMBL319158 0.78 SCN9A (0.45) SCN9ASLC22A12
SCHEMBL1094597 0.77 SCN9A (0.44) SCN9A
SCHEMBL9923651 0.77 SCN9A (0.44) SCN9ASLC22A12
SCHEMBL1094068 0.77 SCN9A (0.60) SCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2385938-A1 SULFONAMIDE DERIVATIVES Pfizer Limited (GB) 2011-11-16 EP disclosed
US-8040476-B2 Display device and method of producing the same MITSUBISHI ELECTRIC CORPORATION (JP) 2011-10-18 US disclosed
WO-2010079443-A1 SULFONAMIDE DERIVATIVES PFIZER LIMITED (GB) 2010-07-15 WO disclosed