Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | TP53 | P04637 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 10/20 | 0.44 |
| ▸ | RAB9A | P51151 | 9/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1742397 | 0.86 | NPC1 (0.57) | MAPTTP53LMNANPC1RAB9A | |
| SCHEMBL1744219 | 0.86 | CYP11B1 (0.45) | HDAC4SCD | |
| SCHEMBL1743158 | 0.82 | NPC1 (0.58) | MAPTTP53LMNANPC1RAB9A | |
| SCHEMBL1744595 | 0.76 | NPC1 (0.56) | MAPTTP53NPC1RAB9AMEN1 | |
| SCHEMBL1742755 | 0.75 | NPC1 (0.61) | MAPTTP53LMNANPC1RAB9A | |
| SCHEMBL1744081 | 0.72 | MAPT (0.41) | MAPTTP53LMNANPC1RAB9A | |
| SCHEMBL1743048 | 0.72 | NPC1 (0.57) | TP53NPC1RAB9AMEN1KMT2A | |
| SCHEMBL1743033 | 0.71 | PTPN1 (0.55) | MAPTTP53NPC1RAB9AMEN1 | |
| SCHEMBL1742851 | 0.71 | NPC1 (0.46) | MAPTTP53LMNANPC1RAB9A | |
| SCHEMBL1742279 | 0.70 | NPC1 (0.58) | MAPTTP53LMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2386554-A1 | Compounds active at the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2011-11-16 | — | — | EP | disclosed |