Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT2 | P31751 | 8/20 | 0.43 |
| ▸ | AKT1 | P31749 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | ILK | Q13418 | 1/20 | 0.33 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.32 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 2/20 | 0.31 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3740850 | 0.72 | AKT2 (0.70) | AKT2AKT1KCNH2CHEK1CHEK2 | |
| Hydrochloric Acid SCHEMBL28973063 | 0.70 | AKT2 (0.67) | AKT2AKT1KCNH2CHEK1CHEK2 | |
| SCHEMBL3150004 | 0.68 | AKT2 (0.47) | AKT2AKT1KCNH2ILKMAPK1 | |
| SCHEMBL16432987 | 0.66 | AKT2 (0.76) | AKT2AKT1ILKAKT3PIM1 | |
| SCHEMBL15689115 | 0.66 | AKT2 (0.76) | AKT2AKT1ILKAKT3PIM1 | |
| SCHEMBL29533228 | 0.66 | AKT2 (0.61) | AKT2AKT1KCNH2CHEK1CHEK2 | |
| SCHEMBL41607 | 0.65 | AKT2 (0.53) | AKT2AKT1KCNH2CHEK1CHEK2 | |
| SCHEMBL4577541 | 0.63 | PDGFRB (0.49) | PIM1 | |
| SCHEMBL197153 | 0.62 | AKT2 (0.61) | AKT2AKT1CHEK1CHEK2ABL1 | |
| SCHEMBL23706596 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3169332-A1 | FOOD INTAKE, BODY WEIGHT AND GLUCOSE METABOLISM REGULATION BY MODULATION OF P2Y6 RECEPTOR SIGNALING | Max-Planck-Gesellschaft zur Förderung der Wissenschaften (DE) | 2017-05-24 | — | — | EP | claimed |
| WO-2016008603-A1 | FOOD INTAKE, BODY WEIGHT AND GLUCOSE METABOLISM REGULATION BY MODULATION OF P2Y6 RECEPTOR SIGNALING | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2016-01-21 | — | — | WO | claimed |
| CN-102933561-B | There is the disubstituted triazine derivatives of pharmaceutical active | Lead Discovery Center Co.,Ltd. (DE) | 2016-05-11 | — | — | CN | disclosed |