SCHEMBL1744513

SCHEMBL1744513

Cc1cc(OCC=C(c2ccc(C#CCN3CCCC3)cc2)c2ccc(C(F)(F)F)cc2)ccc1OC(C)C(=O)O

nearest known ligand 0.49

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 15/20 0.49
PPARA Q07869 3/20 0.43
PPARG P37231 1/20 0.43
HRH3 Q9Y5N1 2/20 0.36
SLC6A4 P31645 1/20 0.36
PTGDR2 Q9Y5Y4 2/20 0.36
MGLL Q99685 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1744511 1.00 PPARD (0.49) PPARDPPARAPPARGHRH3SLC6A4
SCHEMBL1744475 0.93 PPARD (0.51) PPARDPPARAPPARGHRH3SLC6A4
SCHEMBL1744479 0.93 PPARD (0.51) PPARDPPARAPPARGHRH3SLC6A4
SCHEMBL1746555 0.93 PPARD (0.51) PPARDPPARAPPARGHRH3SLC6A4
SCHEMBL1747631 0.93 PPARD (0.47) PPARDPPARAPPARGPTGDR2MGLL
SCHEMBL1747630 0.93 PPARD (0.47) PPARDPPARAPPARGPTGDR2MGLL
SCHEMBL1745246 0.90 PPARD (0.61) PPARDPPARAPPARG
SCHEMBL1745249 0.90 PPARD (0.61) PPARDPPARAPPARG
SCHEMBL1745166 0.90 PPARD (0.43) PPARDPPARAPPARGHRH3
SCHEMBL1747634 0.88 PPARD (0.52) PPARDPPARAPTGDR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2386540-A1 Novel compounds, their preparation and use High Point Pharmaceuticals, LLC (US) 2011-11-16 EP disclosed
US-20110245244-A1 PHENOXY ACETIC ACIDS AS PPAR DELTA ACTIVATORS HIGH POINT PHARMACEUTICALS, LLC (US) 2011-10-06 US disclosed
US-7943613-B2 Compounds, their preparation and use HIGH POINT PHARMACEUTICALS, LLC (US) 2011-05-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110245244-A1 PHENOXY ACETIC ACIDS AS PPAR DELTA ACTIVATORS PPARG, PPARA, PPARD PPARD 3/4885PPARA 2/4885PPARG 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.