Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 3/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.35 |
| ▸ | SSTR2 | P30874 | 2/20 | 0.34 |
| ▸ | SSTR3 | P32745 | 2/20 | 0.34 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.34 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.34 |
| ▸ | CAPN2 | P17655 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.33 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | KLK7 | P49862 | 1/20 | 0.32 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16693722 | 1.00 | TACR1 (0.38) | TACR1MCHR1SSTR2SSTR3SSTR5 | |
| SCHEMBL17640891 | 1.00 | TACR1 (0.38) | TACR1MCHR1SSTR2SSTR3SSTR5 | |
| SCHEMBL17448300 | 1.00 | TACR1 (0.38) | TACR1MCHR1SSTR2SSTR3SSTR5 | |
| SCHEMBL17122691 | 0.97 | TACR1 (0.36) | TACR1MCHR1SSTR2SSTR3SSTR5 | |
| SCHEMBL18973082 | 0.90 | TACR1 (0.34) | TACR1CAPN1CAPN2SIRT2TPSAB1 | |
| SCHEMBL16693711 | 0.90 | TACR1 (0.32) | TACR1 | |
| SCHEMBL17236023 | 0.88 | TACR1 (0.31) | TACR1 | |
| SCHEMBL16250407 | 0.86 | HPSE (0.34) | — | |
| SCHEMBL16905461 | 0.85 | HPSE (0.34) | — | |
| SCHEMBL9604519 | 0.85 | TACR1 (0.35) | TACR1CAPN1CAPN2SIRT2TPSAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382540-B2 | Compositions and methods for modulating angiopoietin-like 3 expression | ISIS PHARMACEUTICALS, INC (US) | 2016-07-05 | — | — | US | disclosed |
| US-20160017323-A1 | CONJUGATED ANTISENSE COMPOUNDS AND THEIR USE | ISIS PHARMACEUTICALS, INC. (US) | 2016-01-21 | — | — | US | disclosed |