Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 16/20 | 0.60 |
| ▸ | PDE3A | Q14432 | 16/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | GALR3 | O60755 | 2/20 | 0.52 |
| ▸ | PDE4A | P27815 | 2/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.50 |
| ▸ | SLFN12 | Q8IYM2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21241618 | 0.90 | PDE3B (0.54) | PDE3BPDE3ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL21241229 | 0.84 | PDE3B (0.54) | PDE3BPDE3ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL21241243 | 0.83 | PDE3B (0.58) | PDE3BPDE3ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL22910053 | 0.82 | PDE3B (0.57) | PDE3BPDE3ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL21241017 | 0.82 | PDE3B (0.53) | PDE3BPDE3ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL22909976 | 0.80 | PDE3B (0.52) | PDE3BPDE3ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL10736534 | 0.80 | PDE3B (0.64) | PDE3BPDE3ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL21241020 | 0.80 | PDE3B (0.54) | PDE3BPDE3ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL21241233 | 0.80 | PDE3B (0.54) | PDE3BPDE3ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL21241019 | 0.80 | PDE3B (0.54) | PDE3BPDE3ASMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160016913-A1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CANCER | THE BROAD INSTITUTE, INC. (US) | 2016-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160016913-A1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CANCER | TP53, RB1, CDK4 | PDE3B 2667/4885PDE3A 2661/4885SMN1; SMN2 3132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.