Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 10/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 10/20 | 0.44 |
| ▸ | LCK | P06239 | 10/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.40 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL897212 | 0.79 | ALK (0.66) | ALK | |
| SCHEMBL897749 | 0.74 | ALK (0.64) | ALKNTRK1LCKKDRNTRK3 | |
| SCHEMBL17448478 | 0.74 | ALK (0.70) | ALK | |
| SCHEMBL898634 | 0.71 | ALK (0.78) | ALK | |
| SCHEMBL20004838 | 0.70 | ALK (0.69) | ALK | |
| SCHEMBL20004840 | 0.70 | ALK (0.69) | ALK | |
| SCHEMBL20366650 | 0.69 | ALK (0.57) | ALKNTRK1LCKKDRNTRK3 | |
| SCHEMBL17448462 | 0.69 | ALK (0.79) | ALK | |
| SCHEMBL897492 | 0.69 | ALK (0.73) | ALKNTRK1LCKKDRNTRK3 | |
| SCHEMBL29962761 | 0.69 | ALK (0.73) | ALKNTRK1LCKKDRNTRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2975024-A1 | TETRACYCLIC COMPOUNDS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2016-01-20 | — | — | EP | disclosed |