Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 11/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 10/20 | 0.47 |
| ▸ | KDR | P35968 | 6/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.47 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 8/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20366650 | 0.89 | ALK (0.57) | ALKNTRK1KDRSRCNTRK3 | |
| SCHEMBL20004305 | 0.89 | ALK (0.57) | ALKNTRK1KDRSRCNTRK3 | |
| SCHEMBL897766 | 0.88 | NTRK1 (0.48) | ALKNTRK1KDRSRCNTRK3 | |
| SCHEMBL897767 | 0.84 | NTRK1 (0.45) | ALKNTRK1KDRSRCNTRK3 | |
| SCHEMBL898127 | 0.77 | ALK (0.58) | ALK | |
| SCHEMBL17448462 | 0.76 | ALK (0.79) | ALK | |
| SCHEMBL20004790 | 0.76 | ALK (0.55) | ALK | |
| SCHEMBL20004307 | 0.76 | ALK (0.58) | ALK | |
| SCHEMBL898634 | 0.76 | ALK (0.78) | ALK | |
| SCHEMBL17448478 | 0.75 | ALK (0.70) | ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2975024-A1 | TETRACYCLIC COMPOUNDS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2016-01-20 | — | — | EP | disclosed |