Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 19/20 | 0.74 |
| ▸ | BMPR1A | P36894 | 12/20 | 0.74 |
| ▸ | ACVRL1 | P37023 | 8/20 | 0.66 |
| ▸ | ACVR1B | P36896 | 7/20 | 0.66 |
| ▸ | BMPR1B | O00238 | 6/20 | 0.66 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.51 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26867177 | 0.89 | ACVR1 (0.76) | ACVR1BMPR1AACVRL1ACVR1BBMPR1B | |
| SCHEMBL26867273 | 0.87 | ACVR1 (0.70) | ACVR1BMPR1AACVRL1ACVR1BBMPR1B | |
| SCHEMBL26867342 | 0.87 | ACVR1 (0.70) | ACVR1BMPR1AACVRL1ACVR1BBMPR1B | |
| SCHEMBL26867287 | 0.87 | ACVR1 (0.69) | ACVR1BMPR1AACVRL1ACVR1BBMPR1B | |
| SCHEMBL17442424 | 0.87 | ACVR1 (0.69) | ACVR1BMPR1AACVRL1ACVR1BBMPR1B | |
| SCHEMBL19123447 | 0.87 | ACVR1 (0.72) | ACVR1BMPR1AACVRL1ACVR1BBMPR1B | |
| SCHEMBL17442388 | 0.87 | ACVR1 (0.69) | ACVR1BMPR1AACVRL1ACVR1BBMPR1B | |
| SCHEMBL17441841 | 0.87 | ACVR1 (0.69) | ACVR1BMPR1AACVRL1ACVR1BBMPR1B | |
| SCHEMBL26867251 | 0.87 | ACVR1 (0.69) | ACVR1BMPR1AACVRL1ACVR1BBMPR1B | |
| SCHEMBL17441857 | 0.86 | ACVR1 (0.85) | ACVR1BMPR1AACVRL1ACVR1BBMPR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016011019-A1 | COMPOSITIONS AND METHODS FOR INHIBITING BMP | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2016-01-21 | — | — | WO | disclosed |