Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 10/20 | 0.65 |
| ▸ | BMPR1A | P36894 | 6/20 | 0.65 |
| ▸ | BMPR1B | O00238 | 4/20 | 0.65 |
| ▸ | ACVR1B | P36896 | 4/20 | 0.65 |
| ▸ | ACVRL1 | P37023 | 4/20 | 0.65 |
| ▸ | KDR | P35968 | 7/20 | 0.52 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.52 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.52 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.45 |
| ▸ | BMPR2 | Q13873 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26867335 | 0.87 | ACVR1 (0.60) | ACVR1BMPR1ABMPR1BACVR1BACVRL1 | |
| SCHEMBL26867327 | 0.87 | ACVR1 (0.60) | ACVR1BMPR1ABMPR1BACVR1BACVRL1 | |
| SCHEMBL24409629 | 0.86 | ACVR1 (0.59) | ACVR1BMPR1ABMPR1BACVR1BACVRL1 | |
| SCHEMBL17442117 | 0.85 | ACVR1 (0.58) | ACVR1BMPR1ABMPR1BACVR1BACVRL1 | |
| SCHEMBL17442436 | 0.85 | ACVR1 (0.58) | ACVR1BMPR1ABMPR1BACVR1BACVRL1 | |
| SCHEMBL17441992 | 0.85 | ACVR1 (0.64) | ACVR1BMPR1ABMPR1BACVR1BACVRL1 | |
| SCHEMBL19124829 | 0.85 | ACVR1 (0.58) | ACVR1BMPR1ABMPR1BACVR1BACVRL1 | |
| SCHEMBL24409603 | 0.85 | ACVR1 (0.60) | ACVR1BMPR1ABMPR1BACVR1BACVRL1 | |
| SCHEMBL17448509 | 0.84 | ACVR1 (0.58) | ACVR1BMPR1ABMPR1BACVR1BACVRL1 | |
| SCHEMBL24409601 | 0.84 | ACVR1 (0.57) | ACVR1BMPR1ABMPR1BACVR1BACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016011019-A1 | COMPOSITIONS AND METHODS FOR INHIBITING BMP | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2016-01-21 | — | — | WO | disclosed |