Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | PTPRB | P23467 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.31 |
| ▸ | CTSS | P25774 | 2/20 | 0.30 |
| ▸ | CTSK | P43235 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1743842 | 0.92 | AKT1 (0.36) | ATMPTPRBPTPN1GSK3BDYRK1A | |
| SCHEMBL2547827 | 0.89 | PTPRB (0.37) | ATMPTPRBPTPN1GSK3BDYRK1A | |
| SCHEMBL2547825 | 0.89 | PTPRB (0.37) | ATMPTPRBPTPN1GSK3BDYRK1A | |
| SCHEMBL1743902 | 0.88 | GSK3B (0.30) | GSK3BDYRK1A | |
| SCHEMBL1744901 | 0.84 | PTPRB (0.35) | ATMPTPRBPTPN1GSK3BDYRK1A | |
| SCHEMBL2546675 | 0.82 | CDK2 (0.32) | GSK3BDYRK1A | |
| SCHEMBL1742991 | 0.82 | AAK1 (0.31) | GSK3BDYRK1A | |
| SCHEMBL2550295 | 0.81 | AKT1 (0.40) | ATMPTPRBGSK3BDYRK1A | |
| SCHEMBL2550309 | 0.81 | AKT1 (0.40) | ATMPTPRBGSK3BDYRK1A | |
| SCHEMBL1742953 | 0.81 | GSK3B (0.37) | GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2387570-A1 | FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE | Amgen, Inc (US) | 2011-11-23 | — | — | EP | disclosed |