SCHEMBL1745112

SCHEMBL1745112

Cc1ccc(C(=CCOc2ccc(OC(C)C(=O)O)c(C)c2)c2ccc(I)cc2)cc1

nearest known ligand 0.48

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 14/20 0.48
PPARG P37231 11/20 0.48
PPARA Q07869 11/20 0.48
TDP1 Q9NUW8 1/20 0.44
TSHR P16473 1/20 0.44
HTR2A P28223 1/20 0.44
HTR2C P28335 1/20 0.44
HTR2B P41595 1/20 0.44
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2510139 1.00 PPARD (0.48) PPARDPPARGPPARATDP1TSHR
SCHEMBL2510142 1.00 PPARD (0.48) PPARDPPARGPPARATDP1TSHR
SCHEMBL1745535 0.92 PPARD (0.48) PPARDPPARGPPARATDP1TSHR
SCHEMBL1747388 0.92 TSHR (0.53) PPARDPPARGPPARATDP1TSHR
SCHEMBL1744324 0.92 TSHR (0.53) PPARDPPARGPPARATDP1TSHR
SCHEMBL1744420 0.92 PPARD (0.46) PPARDPPARGPPARATDP1TSHR
SCHEMBL1744326 0.92 TSHR (0.53) PPARDPPARGPPARATDP1TSHR
SCHEMBL1745537 0.92 PPARD (0.48) PPARDPPARGPPARATDP1TSHR
SCHEMBL1746571 0.92 PPARD (0.48) PPARDPPARGPPARATDP1TSHR
SCHEMBL1744421 0.92 PPARD (0.46) PPARDPPARGPPARATDP1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2386540-A1 Novel compounds, their preparation and use High Point Pharmaceuticals, LLC (US) 2011-11-16 EP disclosed
US-20110245244-A1 PHENOXY ACETIC ACIDS AS PPAR DELTA ACTIVATORS HIGH POINT PHARMACEUTICALS, LLC (US) 2011-10-06 US disclosed
US-7943613-B2 Compounds, their preparation and use HIGH POINT PHARMACEUTICALS, LLC (US) 2011-05-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110245244-A1 PHENOXY ACETIC ACIDS AS PPAR DELTA ACTIVATORS PPARG, PPARA, PPARD PPARD 3/4885PPARG 1/4885PPARA 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.