Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 15/20 | 0.52 |
| ▸ | JAK3 | P52333 | 7/20 | 0.48 |
| ▸ | JAK1 | P23458 | 5/20 | 0.48 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.47 |
| ▸ | PLK4 | O00444 | 3/20 | 0.47 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.47 |
| ▸ | CIT | O14578 | 1/20 | 0.47 |
| ▸ | GAK | O14976 | 1/20 | 0.47 |
| ▸ | OPA1 | O60313 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | STK16 | O75716 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | MARK3 | P27448 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.47 |
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
| ▸ | STAT5A | P42229 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2356388 | 0.91 | JAK2 (0.58) | JAK2JAK3JAK1ACVR1PLK4 | |
| SCHEMBL3709983 | 0.90 | JAK2 (0.56) | JAK2JAK3JAK1ACVR1PLK4 | |
| SCHEMBL2358412 | 0.89 | JAK2 (0.55) | JAK2JAK3JAK1ACVR1PLK4 | |
| SCHEMBL2358356 | 0.89 | JAK2 (0.55) | JAK2JAK3JAK1ACVR1PLK4 | |
| SCHEMBL2356619 | 0.87 | JAK2 (0.50) | JAK2JAK3JAK1ACVR1PLK4 | |
| SCHEMBL2356073 | 0.87 | JAK2 (0.54) | JAK2JAK3JAK1ACVR1PLK4 | |
| SCHEMBL2358315 | 0.87 | JAK2 (0.55) | JAK2JAK3JAK1ACVR1PLK4 | |
| Hydrochloric Acid SCHEMBL4410217 | 0.86 | JAK2 (0.54) | JAK2JAK3JAK1ACVR1PLK4 | |
| SCHEMBL2357999 | 0.86 | JAK2 (0.50) | JAK2JAK3JAK1ACVR1PLK4 | |
| SCHEMBL2359102 | 0.85 | JAK2 (0.54) | JAK2JAK3JAK1ACVR1PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2220068-B1 | 4-PYRAZOLYL-N-ARYLPYRIMIDIN-2-AMINES AND 4-PYRAZOLYL-N-HETEROARYLPYRIMIDIN-2-AMINES AS JANUS KINASE INHIBITORS | INCYTE HOLDINGS CORP (US) | 2016-01-27 | — | — | EP | claimed |