Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 1/20 | 0.78 |
| ▸ | CDK2 | P24941 | 1/20 | 0.78 |
| ▸ | JAK2 | O60674 | 17/20 | 0.76 |
| ▸ | JAK1 | P23458 | 12/20 | 0.76 |
| ▸ | TYK2 | P29597 | 11/20 | 0.76 |
| ▸ | JAK3 | P52333 | 10/20 | 0.76 |
| ▸ | ABL1 | P00519 | 3/20 | 0.76 |
| ▸ | GSK3B | P49841 | 2/20 | 0.76 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.76 |
| ▸ | STAT3 | P40763 | 2/20 | 0.76 |
| ▸ | KDR | P35968 | 1/20 | 0.76 |
| ▸ | FLT3 | P36888 | 7/20 | 0.53 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.49 |
| ▸ | PAK4 | O96013 | 2/20 | 0.49 |
| ▸ | RET | P07949 | 2/20 | 0.49 |
| ▸ | LTK | P29376 | 2/20 | 0.49 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.49 |
| ▸ | CLK2 | P49760 | 2/20 | 0.49 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4409456 | 0.94 | CCNE1 (0.77) | CCNE1CDK2JAK2JAK1TYK2 | |
| SCHEMBL2358701 | 0.93 | CCNE1 (0.75) | CCNE1CDK2JAK2JAK1TYK2 | |
| SCHEMBL2358140 | 0.93 | CCNE1 (0.77) | CCNE1CDK2JAK2JAK1TYK2 | |
| SCHEMBL15388851 | 0.91 | CCNE1 (0.71) | CCNE1CDK2JAK2JAK1TYK2 | |
| SCHEMBL2356232 | 0.91 | JAK2 (0.82) | CCNE1CDK2JAK2JAK1TYK2 | |
| SCHEMBL15388848 | 0.91 | CCNE1 (0.74) | CCNE1CDK2JAK2JAK1TYK2 | |
| SCHEMBL3302134 | 0.90 | CCNE1 (0.76) | CCNE1CDK2JAK2JAK1TYK2 | |
| SCHEMBL3309993 | 0.90 | CCNE1 (0.71) | CCNE1CDK2JAK2JAK1TYK2 | |
| SCHEMBL2359390 | 0.90 | CCNE1 (0.75) | CCNE1CDK2JAK2JAK1TYK2 | |
| SCHEMBL2358683 | 0.89 | JAK2 (0.79) | CCNE1CDK2JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2220068-B1 | 4-PYRAZOLYL-N-ARYLPYRIMIDIN-2-AMINES AND 4-PYRAZOLYL-N-HETEROARYLPYRIMIDIN-2-AMINES AS JANUS KINASE INHIBITORS | INCYTE HOLDINGS CORP (US) | 2016-01-27 | — | — | EP | claimed |