Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.39 |
| ▸ | BACE1 | P56817 | 3/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17453057 | 0.90 | BACE1 (0.41) | BACE2BACE1AKR1B1ALDH1A1HIF1A | |
| SCHEMBL10328607 | 0.84 | BACE2 (0.43) | BACE2BACE1AKR1B1ALDH1A1HIF1A | |
| SCHEMBL17652908 | 0.84 | BACE2 (0.43) | BACE2BACE1AKR1B1ALDH1A1HIF1A | |
| SCHEMBL29554687 | 0.84 | BACE2 (0.43) | BACE2BACE1AKR1B1ALDH1A1HIF1A | |
| SCHEMBL17453066 | 0.83 | BACE2 (0.39) | BACE2BACE1AKR1B1ADRA2APNMT | |
| SCHEMBL17453064 | 0.80 | BACE2 (0.36) | BACE2BACE1ALDH1A1GAATHRB | |
| SCHEMBL19221039 | 0.75 | BACE1 (0.44) | BACE2BACE1AKR1B1ALDH1A1HIF1A | |
| SCHEMBL13466034 | 0.74 | BACE1 (0.47) | BACE2BACE1AKR1B1ADRA2APNMT | |
| SCHEMBL13466659 | 0.74 | BACE1 (0.44) | BACE2BACE1ADRA2APNMTADRA2B | |
| SCHEMBL13466444 | 0.74 | BACE1 (0.44) | BACE2BACE1ADRA2APNMTADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9428476-B2 | S-imino-S-oxo-iminothiadiazine compounds as BACE inhibitors, compositions, and their use | MERCK SHARP & DOHME CORP. (US) | 2016-08-30 | — | — | US | disclosed |
| US-9428476-B2 | S-imino-S-oxo-iminothiadiazine compounds as BACE inhibitors, compositions, and their use | MERCK SHARP & DOHME CORP. (US) | 2016-08-30 | — | — | US | disclosed |
| US-20160016923-A1 | S-IMINO-S-OXO-IMINOTHIADIAZINE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME CORP. (US) | 2016-01-21 | — | — | US | disclosed |
| US-20160016923-A1 | S-IMINO-S-OXO-IMINOTHIADIAZINE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME CORP. (US) | 2016-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160016923-A1 | S-IMINO-S-OXO-IMINOTHIADIAZINE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE | BACE1, BACE2, APP | BACE2 2/4885BACE1 1/4885AKR1B1 188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.