Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 9/20 | 0.50 |
| ▸ | BCL9 | O00512 | 8/20 | 0.50 |
| ▸ | CHUK | O15111 | 3/20 | 0.48 |
| ▸ | IKBKB | O14920 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | PRKACA | P17612 | 1/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
| ▸ | CLK2 | P49760 | 1/20 | 0.45 |
| ▸ | PRKX | P51817 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17456032 | 0.84 | ROCK1 (0.52) | CTNNB1BCL9CHUKIKBKBHTR1A | |
| SCHEMBL23161332 | 0.79 | SLC6A2 (0.64) | CTNNB1BCL9HTR1ASLC6A2HTR2C | |
| Hydrochloric Acid SCHEMBL72907 | 0.77 | SLC6A2 (0.62) | CTNNB1BCL9HTR1ASLC6A2HTR2C | |
| Hydrochloric Acid SCHEMBL23146510 | 0.77 | SLC6A2 (0.62) | CTNNB1BCL9HTR1ASLC6A2HTR2C | |
| SCHEMBL30791461 | 0.76 | HRH1 (0.65) | CTNNB1BCL9HTR1ASLC6A2HTR2C | |
| SCHEMBL15062008 | 0.76 | HTR2C (0.54) | CTNNB1BCL9HTR1ASLC6A2HTR2C | |
| SCHEMBL3880092 | 0.76 | SLC6A2 (0.54) | CTNNB1BCL9CHUKIKBKBHTR1A | |
| SCHEMBL15076157 | 0.76 | HTR2C (0.54) | CTNNB1BCL9HTR1ASLC6A2HTR2C | |
| SCHEMBL2944352 | 0.76 | SLC6A2 (0.54) | CTNNB1BCL9CHUKIKBKBHTR1A | |
| SCHEMBL15062009 | 0.76 | HTR2C (0.54) | CTNNB1BCL9HTR1ASLC6A2HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2982666-B1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICALS CO (JP) | 2019-08-07 | — | — | EP | disclosed |
| US-9598398-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-03-21 | — | — | US | disclosed |
| EP-2982666-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2016-02-10 | — | — | EP | disclosed |
| US-20160024049-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160024049-A1 | HETEROCYCLIC COMPOUND | PSEN1, PSEN2, BACE1 | CTNNB1 1293/4885BCL9 2995/4885CHUK 1104/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.