Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 19/20 | 0.67 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.67 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.66 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.65 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.65 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.65 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.65 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.65 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.65 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.65 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30267926 | 1.00 | HDAC1 (0.67) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL17457480 | 1.00 | HDAC1 (0.67) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL29628887 | 0.89 | HDAC1 (0.52) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL17472002 | 0.89 | HDAC1 (0.52) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL25110338 | 0.88 | HDAC1 (0.72) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL17472418 | 0.84 | HDAC1 (0.58) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL17457473 | 0.84 | HDAC2 (0.65) | HDAC1HDAC2HDAC3 | |
| SCHEMBL17457471 | 0.84 | HDAC2 (0.65) | HDAC1HDAC2HDAC3 | |
| SCHEMBL1066862 | 0.83 | HDAC1 (0.71) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL2209850 | 0.82 | HDAC1 (0.70) | HDAC1HDAC2HDAC3HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970107-B1 | PHOTOSWITCHABLE HDAC INHIBITORS | MASSACHUSETTS GEN HOSPITAL (US) | 2023-11-15 | — | — | EP | disclosed |
| US-11596691-B2 | Photoswitchable HDAC inhibitors | THE GENERAL HOSPITAL CORPORATION (US) | 2023-03-07 | — | — | US | disclosed |
| US-20210162048-A1 | Photoswitchable HDAC Inhibitors | THE GENERAL HOSPITAL CORPORATION | 2021-06-03 | — | — | US | disclosed |
| US-10828367-B2 | Photoswitchable HDAC inhibitors | THE GENERAL HOSPITAL CORPORATION (US) | 2020-11-10 | — | — | US | disclosed |
| US-20190070295-A1 | Photoswitchable HDAC Inhibitors | THE GENERAL HOSPITAL CORPORATION | 2019-03-07 | — | — | US | disclosed |
| US-9981038-B2 | Photoswitchable HDAC inhibitors | THE GENERAL HOSPITAL CORPORATION (US) | 2018-05-29 | — | — | US | disclosed |
| US-20160022817-A1 | Photoswitchable HDAC Inhibitors | THE GENERAL HOSPITAL CORPORATION (US) | 2016-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190070295-A1 | Photoswitchable HDAC Inhibitors | HDAC4, HDAC1, HDAC3 | HDAC1 2/4885HDAC2 7/4885HDAC3 3/4885 |
| US-20160022817-A1 | Photoswitchable HDAC Inhibitors | HDAC1, HDAC4, HDAC3 | HDAC1 1/4885HDAC2 4/4885HDAC3 3/4885 |
| US-20210162048-A1 | Photoswitchable HDAC Inhibitors | HDAC4, HDAC1, HDAC3 | HDAC1 2/4885HDAC2 7/4885HDAC3 3/4885 |
| US-11596691-B2 | Photoswitchable HDAC inhibitors | HDAC4, HDAC1, HDAC3 | HDAC1 2/4885HDAC2 7/4885HDAC3 3/4885 |
| US-10828367-B2 | Photoswitchable HDAC inhibitors | HDAC4, HDAC1, HDAC3 | HDAC1 2/4885HDAC2 7/4885HDAC3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.